Research Articles
Neurobiological Mechanisms of Addiction Relapse Vulnerability: From Neural Circuits to Clinical Biomarkers
This article synthesizes current research on the neurobiological underpinnings of addiction relapse vulnerability, addressing the needs of researchers and drug development professionals.
Animal Models in Addiction Neurobiology: From Mechanisms to Translation
This article provides a comprehensive resource for researchers and drug development professionals on the use of animal models in addiction neurobiology.
Neuroimaging in Addiction Research: From Mechanisms to Clinical Translation
This article provides a comprehensive overview of current neuroimaging techniques and their application in human addiction research.
From Use to Dependence: Decoding the Neurobiological Transition to Addiction
This article synthesizes current neuroscience research to elucidate the neurobiological mechanisms underlying the transition from voluntary substance use to compulsive addiction.
The Evolving Brain in Addiction: A Lifespan Perspective on Neural Mechanisms and Clinical Translation
This article synthesizes current research on the neurobiological mechanisms of substance use disorders (SUDs) across the human lifespan.
Neuroplasticity in Addiction: From Maladaptive Rewiring to Therapeutic Recovery
This article provides a comprehensive analysis of the dual role of neuroplasticity in substance use disorders, exploring both its contribution to addiction development and its potential as a mechanism for...
Sex Differences in the Addicted Brain: From Neural Circuits to Personalized Treatment
This article synthesizes current research on the distinct neural correlates of substance use disorders (SUDs) in males and females.
Decoding Susceptibility: The Genetic and Epigenetic Architecture of Addiction
This review synthesizes current evidence on the genetic and epigenetic mechanisms underlying individual susceptibility to substance use disorders.
Neuroadaptations in Addiction: Decoding Incentive Salience and Negative Reinforcement Mechanisms
This article synthesizes contemporary neuroscience research to elucidate the neuroadaptations that underpin the transition from controlled substance use to addiction.
Dopamine Reward Prediction Errors: From Learning Signal to Addiction Mechanism
This article synthesizes contemporary neuroscience research on how dopamine-mediated reward prediction errors (RPEs)—a fundamental teaching signal in associative learning—become pathological in substance use disorders.