Research Articles
Beyond Willpower: Decoding the Neurobiological Mechanisms of Addiction Treatment Resistance
This article synthesizes current neuroscience research to explore the core neurobiological mechanisms underlying treatment-resistant addiction.
Overcoming Neurobiological Tolerance: Mechanisms, Models, and Novel Therapeutic Avenues in Addiction Research
This article synthesizes current research on neuroadaptations driving tolerance in substance use disorders, a key challenge in addiction therapeutics.
Modeling Compulsive Drug Seeking: Advanced Animal Models for Addiction Research and Therapeutic Development
This comprehensive review explores the evolution, application, and validation of animal models for studying compulsive drug-seeking behavior—a core feature of substance use disorders.
The Executive Control Paradox: Unraveling Craving Circuits with fMRI in Addiction Neuroscience
This review synthesizes current evidence from functional magnetic resonance imaging (fMRI) studies to elucidate the complex interplay between craving and executive function in substance use disorders.
Individual Differences in Addiction Neurobiology: From Genetic Risk to Personalized Treatment
This article synthesizes current research on the neurobiological basis of individual differences in addiction vulnerability, progression, and treatment response.
Bridging the Gap: Translating Addiction Neurobiology into Effective Clinical Treatments
This article examines the critical challenges and emerging solutions in translating advances in addiction neuroscience into effective clinical treatments for substance use disorders (SUDs).
Beyond the Reward Pathway: Emerging Neurobiological Targets for Next-Generation Addiction Therapeutics
This article synthesizes the latest advancements in addiction neuroscience to provide a strategic overview for researchers and drug development professionals.
Computational Modeling of Dopamine in Addiction: From Circuits to Clinical Translation
This article provides a comprehensive overview for researchers and drug development professionals on how computational modeling is revolutionizing our understanding of dopaminergic dysfunction in addiction.
Implementing the Addictions Neuroclinical Assessment: A Neuroscientific Framework for Precision Medicine in Addiction
The Addictions Neuroclinical Assessment (ANA) is a transformative, neuroscience-based framework designed to address the profound clinical heterogeneity of Substance Use Disorders (SUDs) by focusing on three core neurofunctional domains: Incentive...
Neuromodulation Therapies for Substance Use Disorders: A Comprehensive Review of Mechanisms, Efficacy, and Future Directions
Substance use disorders (SUDs) represent a major global health challenge with high relapse rates despite available treatments.