Research Articles
Sex Differences in the Addicted Brain: From Neural Circuits to Personalized Treatment
This article synthesizes current research on the distinct neural correlates of substance use disorders (SUDs) in males and females.
Decoding Susceptibility: The Genetic and Epigenetic Architecture of Addiction
This review synthesizes current evidence on the genetic and epigenetic mechanisms underlying individual susceptibility to substance use disorders.
Neuroadaptations in Addiction: Decoding Incentive Salience and Negative Reinforcement Mechanisms
This article synthesizes contemporary neuroscience research to elucidate the neuroadaptations that underpin the transition from controlled substance use to addiction.
Dopamine Reward Prediction Errors: From Learning Signal to Addiction Mechanism
This article synthesizes contemporary neuroscience research on how dopamine-mediated reward prediction errors (RPEs)—a fundamental teaching signal in associative learning—become pathological in substance use disorders.
The Addicted Brain: A Neurocircuitry Analysis of the Basal Ganglia, Extended Amygdala, and Prefrontal Cortex
This article provides a comprehensive neurobiological framework for substance use disorders, focusing on the dynamic interplay between the basal ganglia, extended amygdala, and prefrontal cortex.
Neurobiological Mechanisms of Addiction: Bridging Foundational Science to Clinical Translation and Drug Development
This article provides a comprehensive synthesis of current research on the neurobiological underpinnings of addiction, tailored for researchers, scientists, and drug development professionals.
Validating Functional Connectivity Metrics Across Imaging Modalities: A Roadmap for Robust Biomarker Development
This article provides a comprehensive framework for the validation of functional connectivity (FC) metrics across diverse neuroimaging modalities, including fMRI, EEG, and DTI.
Combating Participant Fatigue in Long-Duration Neuroimaging Studies: A Strategic Guide for Researchers
This article provides a comprehensive framework for understanding and mitigating participant fatigue in extended neurological experiments and clinical trials.
Environmental Enrichment and Neural Plasticity: A Comparative Analysis of Mechanisms and Therapeutic Applications
This article provides a comprehensive comparative analysis of environmental enrichment (EE) and its profound impact on neural plasticity, tailored for researchers, scientists, and drug development professionals.
Validating Neurogenesis Measurement Methods: From Foundational Techniques to Clinical Biomarkers
This article provides a comprehensive review of the methodologies for validating adult neurogenesis measurement, addressing the critical needs of researchers, scientists, and drug development professionals.